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Polymorphisms in nonhomologous end-joining genes associated with breast cancer risk and chromosomal radiosensitivity.

Genes, chromosomes & cancer - 1 Feb 2008

Willems Petra, Claes Kathleen, Baeyens Ans, Vandersickel Veerle, Werbrouck Joke, De Ruyck Kim, Poppe Bruce, Van den Broecke Rudy, Makar Amin, Marras Emanuela, Perletti Gianpaolo, Thierens Hubert, Vral Anne

Abstract excerpt

As enhanced chromosomal radiosensitivity (CRS) results from non- or misrepaired double strand breaks (DSBs) and is a hallmark for breast cancer and single nucleotide polymorphisms (SNPs) in DSB repair genes, such as non homologous end-joining (NHEJ) genes, could be involved in CRS and genetic predisposition to breast cancer. In this study, we investigated the association of five SNPs in three different NHEJ genes...

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PMID: 18000863
DOI: 10.1002/gcc.20515

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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