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Article

Human p53 phosphorylation mimic, S392E, increases nonspecific DNA affinity and thermal stability.

Biochemistry - 8 Jan 2002

Nichols Nicole Magnasco, Matthews Kathleen Shive

Abstract excerpt

DNA binding is crucial to the protective role of the tumor suppressor protein p53, a nuclear phosphoprotein and transcription factor. The mutant human p53 protein S392E is a phosphorylation mimic that has been previously demonstrated to represent an "activated" form of p53 in both in vivo and in vitro assays [Hupp and Lane (1995) J. Biol. Chem. 270, 18165; Hao et al. (1996) J. Biol. Chem. 271, 29380]. Herein, we...

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PMID: 11772014
DOI: 10.1021/bi011736r

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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