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Article

The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.

Journal of molecular biology - 14 Jul 2000

Luciani M G, Hutchins J R, Zheleva D, Hupp T R

Abstract excerpt

Radiation injury to cells enhances C-terminal phosphorylation of p53 at both Ser315 and Ser392 in vivo, suggesting the existence of two cooperating DNA damage-responsive pathways that play a role in stimulating p53-dependent gene expression. Our previous data has shown that cyclin A-cdk2 is the major enzyme responsible for modifying p53 at Ser315 in vivo after irradiation damage and in this report we dissect the...

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Identifiers

PMID: 10884347
DOI: 10.1006/jmbi.2000.3830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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