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Article

Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer.

Cancer research - 15 Jul 2004

Biswas Swati, Chytil Anna, Washington Kay, Romero-Gallo Judith, Gorska Agnieszka E, Wirth Pamela S, Gautam Shiva, Moses Harold L, Grady William M

Abstract excerpt

Deregulation of members of the transforming growth factor (TGF)-beta signaling pathway occurs often in colon cancers and is believed to affect the formation of primary colon cancer. Mutational inactivation of TGFBR2 is the most common genetic event affecting the TGF-beta signaling pathway and occurs in approximately 20-30% of all colon cancers. By mating Fabpl(4xat-132) Cre mice with Tgfbr2(flx/flx) mice, we have...

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Source

Identifiers

PMID: 15256431
DOI: 10.1158/0008-5472.CAN-03-3255

Genes

TGFBR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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