Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inactivation of TGF-β signaling and loss of PTEN cooperate to induce colon cancer in vivo.

Oncogene - 20 Mar 2014

Yu M, Trobridge P, Wang Y, Kanngurn S, Morris S M, Knoblaugh S, Grady W M

Abstract excerpt

The accumulation of genetic and epigenetic alterations mediates colorectal cancer (CRC) formation by deregulating key signaling pathways in cancer cells. In CRC, one of the most commonly inactivated signaling pathways is the transforming growth factor-beta (TGF-β) signaling pathway, which is often inactivated by mutations of TGF-β type II receptor (TGFBR2). Another commonly deregulated pathway in CRC is the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinases

Share to Gene Knockout Techniques

Share to Intestinal Mucosa

Share to PTEN Phosphohydrolase

Share to Receptor, Transforming Growth Factor-beta Type II

Share to Receptors, Transforming Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 23604118
DOI: 10.1038/onc.2013.102
PMCID: PMC3883899

Genes

PTEN
TGFBR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inactivation of TGF-β signaling and loss of PTEN cooperate to induce colon cancer in vivo.PMID 23604118Read ↗

TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.Semantic proximity Read ↗

Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation.Semantic proximity Read ↗

PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine.Semantic proximity Read ↗

TGF-β signaling in liver and gastrointestinal cancers.Semantic proximity Read ↗

Transforming Growth Factor-β Signaling Pathway in Colorectal Cancer and Its Tumor MicroenvironmentSemantic proximity Read ↗

Combined Mutation of Apc, Kras, and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer.Semantic proximity Read ↗

Tgf-beta signaling alterations and colon cancer.Semantic proximity Read ↗

Conditional abrogation of transforming growth factor-β receptor 1 in PTEN-inactivated endometrium promotes endometrial cancer progression in mice.Semantic proximity Read ↗

Smad4-mediated TGF-β signaling in tumorigenesisSemantic proximity Read ↗

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis.Semantic proximity Read ↗

An inducible knockout mouse to model the cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias.Semantic proximity Read ↗

Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-βSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.