Article

Pla2g2a Attenuates Colon Tumorigenesis in Azoxymethane-Treated C57BL/6 Mice; Expression Studies Reveal Pla2g2a Target Genes and Pathways

2009-01-01

Abstract excerpt

Background : The group IIA secretory phospholipase A2 gene, Pla2g2a , confers resistance to intestinal tumorigenesis in the Apc Min/+ mouse model. However, it is unclear how Pla2g2a exerts its tumor-suppressive effects and whether its mode of action depends on Apc-germline mutations. Methods : We tested whether expression of a Pla2g2a transgene provides protection against carcinogen-induced colon tumors, and exami...

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Literature Corpus work: 3356d279-31a7-5706-ad3f-243081371989
DOI: 10.1155/2009/234121

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