Article
TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.
Gastroenterology - 1 May 2009
Trobridge Patty, Knoblaugh Sue, Washington M Kay, Munoz Nina M, Tsuchiya Karen D, Rojas Andres, Song Xiaoling, Ulrich Cornelia M, Sasazuki Takehiko, Shirasawa Senji, Grady William M
Abstract excerpt
BACKGROUND & AIMS: During colorectal cancer pathogenesis, mutations and epigenetic events cause neoplastic behavior in epithelial cells by deregulating the Wnt, Ras-Raf-extracellular signal-regulated kinase (ERK), and transforming growth factor (TGF)-beta-signaling pathways, among others. The TGF-beta-signaling pathway is often inactivated in colon cancer cells by mutations in the gene encoding the TGF-beta...
Topics
- Animals
- Cell Line, Tumor
- Cell Proliferation
- Gene Expression
- Genes, ras
- Humans
- Intestinal Mucosa
- Intestinal Neoplasms
- Mice
- Mice, Transgenic