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Article

Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation.

Cancer research - 15 Oct 2006

Muñoz Nina M, Upton Melissa, Rojas Andres, Washington M Kay, Lin Li, Chytil Anna, Sozmen Elif G, Madison Blair B, Pozzi Ambra, Moon Randall T, Moses Harold L, Grady William M

Abstract excerpt

The transforming growth factor-beta (TGF-beta) signaling pathway is a tumor-suppressor pathway that is commonly inactivated in colon cancer. TGF-beta is a secreted ligand that mediates its effects through a transmembrane heteromeric receptor complex, which consists of type I (TGFBR1) and type II subunits (TGFBR2). Approximately 30% of colon cancers carry TGFBR2 mutations, demonstrating that it is a common target...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Transforming Growth Factor-beta Type II

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Source

Identifiers

PMID: 17047044
DOI: 10.1158/0008-5472.CAN-06-0890

Genes

TGFBR2
TGFBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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