Article
Genetic signatures of high- and low-risk aberrant crypt foci in a mouse model of sporadic colon cancer.
Cancer research - 15 Sept 2004
Nambiar Prashant R, Nakanishi Masako, Gupta Rishi, Cheung Evelyn, Firouzi Ali, Ma Xiao-Jun, Flynn Christopher, Dong Mei, Guda Kishore, Levine Joel, Raja Rajiv, Achenie Luke, Rosenberg Daniel W
Abstract excerpt
To determine whether cancer risk is related to histopathological features of preneoplastic aberrant crypt foci (ACF), gene expression analysis was performed on ACF from two mouse strains with differing tumor sensitivity to the colonotropic carcinogen, azoxymethane. ACF from sensitive A/J mice were considered at high risk, whereas ACF from resistant AKR/J mice were considered at low risk for tumorigenesis. A/J and...
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