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Article

Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis.

Cancer research - 15 Jan 2007

Fichera Alessandro, Little Nathaniel, Jagadeeswaran Sujatha, Dougherty Urszula, Sehdev Amikar, Mustafi Reba, Cerda Sonia, Yuan Weihua, Khare Sharad, Tretiakova Maria, Gong Can, Tallerico Michael, Cohen Greg, Joseph Loren, Hart John, Turner Jerrold R, Bissonnette Marc

Abstract excerpt

Colonic carcinogenesis involves the progressive dysregulation of homeostatic mechanisms that control growth. The epidermal growth factor (EGF) receptor (EGFR) regulates colonocyte growth and differentiation and is overexpressed in many human colon cancers. A requirement for EGFR in colonic premalignancy, however, has not been shown. In the current study, we used a specific EGFR antagonist, gefitinib, to...

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Identifiers

PMID: 17234795
DOI: 10.1158/0008-5472.CAN-05-3343
PMCID: PMC2705749

Genes

EGFR
EGF

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Source receipt: pubmed, retrieved 7 Sept 2026.

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