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Article

Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis.

Cancer research - 15 Jul 1999

Engle S J, Hoying J B, Boivin G P, Ormsby I, Gartside P S, Doetschman T

Abstract excerpt

The transforming growth factor beta (TGF-beta) pathway is known to play an important role in both human and urine colon cancer. However, the staging, ligand specificity, and mechanism underlying the tumor suppressive activity of this pathway are unknown. We developed a mouse model for colon cancer that identifies an early role for TGF-beta1 in tumor suppression and implicates TGF-beta2 or TGF-beta3 in the...

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PMID: 10416598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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