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Article

Preliminary analysis of azoxymethane induced colon tumors in inbred mice commonly used as transgenic/knockout progenitors.

International journal of oncology - 1 Jan 2003

Nambiar Prashant R, Girnun Geoff, Lillo Nicholas A, Guda Kishore, Whiteley Herbert E, Rosenberg Daniel W

Abstract excerpt

Azoxymethane (AOM) is a colon carcinogen that is used to study the pathogenesis of sporadic colorectal cancer. We have evaluated differential susceptibility to AOM in inbred mice used as progenitors of recombinant/transgenic lines. In experiment 1, male FVB/N, 129/SvJ, C57Bl/6J mice were treated i.p. with 10 mg/kg AOM once per week for 4 weeks and sacrificed after 20 weeks. Only AOM-treated FVB/N mice developed...

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PMID: 12469197

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