Article
TP53 in gastric cancer: mutations in the l3 loop and LSH motif DNA-binding domains of TP53 predict poor outcome.
Journal of cellular physiology - 1 Sept 2004
Migliavacca Manuela, Ottini Laura, Bazan Viviana, Agnese Valentina, Corsale Simona, Macaluso Marcella, Lupi Ramona, Dardanoni Gabriella, Valerio Maria Rosaria, Pantuso Gianni, Di Fede Gaetana, Tomasino Rosa Maria, Gebbia Nicola, Mariani-Costantini Renato, Russo Antonio
Abstract excerpt
The aim of this study was to clarify whether specific p53 mutations may have biological relevance in terms of disease relapse or death in gastric carcinomas (GC). Resected specimens from a consecutive series of 62 patients with GC undergoing potentially curative surgery were prospectively studied. The mutational status of exons 5-8 of the p53 gene was investigated in 62 cases using the PCR-SSCP and sequencing....
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