Article
Mutation spectrum of TP53 gene predicts clinicopathological features and survival of gastric cancer.
Oncotarget - 5 Jul 2016
Tahara Tomomitsu, Shibata Tomoyuki, Okamoto Yasuyuki, Yamazaki Jumpei, Kawamura Tomohiko, Horiguchi Noriyuki, Okubo Masaaki, Nakano Naoko, Ishizuka Takamitsu, Nagasaka Mitsuo, Nakagawa Yoshihito, Ohmiya Naoki
Abstract excerpt
BACKGROUND AND AIM: TP53 gene is frequently mutated in gastric cancer (GC), but the relationship with clinicopathological features and prognosis is conflicting. Here, we screened TP53 mutation spectrum of 214 GC patients in relation to their clinicopathological features and prognosis. RESULTS: TP53 nonsilent mutations were detected in 80 cases (37.4%), being frequently occurred as C:G to T:A single nucleotide...
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