Article
Specific TP53 and/or Ki-ras mutations as independent predictors of clinical outcome in sporadic colorectal adenocarcinomas: results of a 5-year Gruppo Oncologico dell'Italia Meridionale (GOIM) prospective study.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 May 2005
Bazan V, Agnese V, Corsale S, Calò V, Valerio M R, Latteri M A, Vieni S, Grassi N, Cicero G, Dardanoni G, Tomasino R M, Colucci G, Gebbia N, Russo A
Abstract excerpt
BACKGROUND: Although Ki-ras and TP53 mutations have probably been the genetic abnormalities most exhaustively implicated and studied in colorectal cancer (CRC) progression, their significance in terms of disease relapse and overall survival has not yet clearly been established. PATIENTS AND METHODS: A prospective study was carried out on paired tumor and normal colon tissue samples from a consecutive series of...
Topics
- Adenocarcinoma
- Aged
- Antineoplastic Combined Chemotherapy Protocols
- Chemotherapy, Adjuvant
- Colorectal Neoplasms
- Disease Progression
- Female
- Fluorouracil
- Humans