p53 mutations in L3-loop zinc-binding domain, DNA-ploidy, and S phase fraction are independent prognostic indicators in colorectal cancer: a prospective study with a five-year follow-up.

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p53 mutations in L3-loop zinc-binding domain, DNA-ploidy, and S phase fraction are independent prognostic indicators in colorectal cancer: a prospective study with a five-year follow-up.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2002

Russo Antonio, Migliavacca Manuela, Zanna Ines, Valerio Maria Rosaria, Latteri Mario Adelfio, Grassi Nello, Pantuso Gianni, Salerno Sergio, Dardanoni Gabriella, Albanese Ida, La Farina Mario, Tomasino Rosa Maria, Gebbia Nicola, Bazan Viviana

Abstract excerpt

p53 gene alterations are among the most common events observed in colorectal cancer,and are accompanied frequently by DNA aneuploidy and high proliferative activity. The prognostic significance of such mutations remains controversial. We prospectively evaluated the prognostic significance of p53 mutations, DNA-ploidy, and S phase fraction (SPF) in a consecutive series of 160 colorectal cancer patients (median...

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PMID: 12433709

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