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Article

Chromosomal instability rather than p53 mutation is associated with response to neoadjuvant cisplatin-based chemotherapy in gastric carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2003

Ott Katja, Vogelsang Holger, Mueller James, Becker Karen, Müller Martina, Fink Ulrich, Siewert Jörg Rüdiger, Höfler Heinz, Keller Gisela

Abstract excerpt

PURPOSE: The objective of the study was to evaluate microsatellite alterations [microsatellite instability (MSI) and loss of heterozygosity (LOH)] and mutation in the p53 gene in relation to response and patient survival to a cisplatin-based neoadjuvant chemotherapy in gastric cancer. EXPERIMENTAL DESIGN: Fifty-three pretherapeutic gastric carcinoma biopsies were analyzed with 11 microsatellite markers. The...

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PMID: 12796400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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