Article
The p53 gene in patients under the age of 40 with gastric cancer: mutation rates are low but are associated with a cardiac location.
Molecular pathology : MP - 1 Aug 2000
Rugge M, Shiao Y H, Busatto G, Cassaro M, Strobbe C, Russo V M, Leo G, Parenti A R, Scapinello A, Arslan P, Egarter-Vigl E
Abstract excerpt
BACKGROUND: Determining both the frequency and the spectrum of p53 gene mutation in young patients with gastric cancer might provide clues to the host related genetic mechanism(s) in gastric carcinogenesis. PATIENTS AND METHODS: p53 mutations were assessed (by means of polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP), followed by DNA sequencing) in a cohort of 105 consecutive Italian...
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