Article
Detection and possible prognostic relevance of p53 gene mutations in diffuse large B-cell lymphoma. An analysis of 51 cases and review of the literature.
Leukemia & lymphoma - 1 Oct 2004
Kerbauy Fábio R, Colleoni Gisele W B, Saad Sara T O, Regis Silva Maria Regina, Correa Alves Antonio, Aguiar Kátia C C, Albuquerque Dulcinéia M, Kobarg Jörg, Seixas Maria Tereza, Kerbauy José
Abstract excerpt
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma. Although the presence of p53 gene mutations has been considered as a bad prognostic feature in DLBCL, its clinical significance is still controversial. The aims of this study were: detect the presence of mutations in exons 5 to 9 of the p53 gene and correlate it to prognosis in DLBCL. Fifty-one DLBCL patients were enrolled in...
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