Prediction of TP53 mutations by p53 immunohistochemistry and their prognostic significance in gastric cancer

Abstract excerpt

BACKGROUND: Recently, molecular classifications of gastric cancer (GC) have been proposed that include TP53 mutations and their functional activity. We aimed to demonstrate the correlation between p53 immunohistochemistry (IHC) and TP53 mutations as well as their clinicopathological significance in GC. METHODS: Deep targeted sequencing was performed using surgical or biopsy specimens from 120 patients with GC....

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