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Article

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells.

Molecular and cellular biology - 1 Aug 2004

Murakami Mirei, Ichisaka Tomoko, Maeda Mitsuyo, Oshiro Noriko, Hara Kenta, Edenhofer Frank, Kiyama Hiroshi, Yonezawa Kazuyoshi, Yamanaka Shinya

Abstract excerpt

TOR is a serine-threonine kinase that was originally identified as a target of rapamycin in Saccharomyces cerevisiae and then found to be highly conserved among eukaryotes. In Drosophila melanogaster, inactivation of TOR or its substrate, S6 kinase, results in reduced cell size and embryonic lethality, indicating a critical role for the TOR pathway in cell growth control. However, the in vivo functions of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15254238
DOI: 10.1128/MCB.24.15.6710-6718.2004
PMCID: PMC444840

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells.PMID 15254238Read ↗

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S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy.Semantic proximity Read ↗

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