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Article

Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability.

Developmental cell - 1 Oct 2006

Shiota Chiyo, Woo Jeong-Taek, Lindner Jill, Shelton Kathy D, Magnuson Mark A

Abstract excerpt

The rapamycin-insensitive mTOR complex 2 (mTORC2) has been suggested to play an important role in growth factor-dependent signaling. To explore this possibility further in a mammalian model system, we disrupted the expression of rictor, a specific component of mTORC2, in mice by using a multialle...

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Identifiers

PMID: 16962829
DOI: 10.1016/j.devcel.2006.08.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16962829-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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