Article
S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway.
Molecular and cellular biology - 1 Apr 2004
Pende Mario, Um Sung Hee, Mieulet Virginie, Sticker Melanie, Goss Valerie L, Mestan Jurgen, Mueller Matthias, Fumagalli Stefano, Kozma Sara C, Thomas George
Abstract excerpt
Activation of 40S ribosomal protein S6 kinases (S6Ks) is mediated by anabolic signals triggered by hormones, growth factors, and nutrients. Stimulation by any of these agents is inhibited by the bacterial macrolide rapamycin, which binds to and inactivates the mammalian target of rapamycin, an S6K kinase. In mammals, two genes encoding homologous S6Ks, S6K1 and S6K2, have been identified. Here we show that mice...
Topics
- Animals
- Animals, Newborn
- Cell Cycle
- Embryo, Mammalian
- Enzyme Activation
- Female
- Fetal Viability
- Genotype
- MAP Kinase Signaling System
- Male