Article

Depletion of Ric-8B leads to reduced mTORC2 activity

2019-06-19

Abstract excerpt

mTOR, a serine/threonine protein kinase that is involved in a series of critical cellular processes, can be found in two functionally distinct complexes, mTORC1 and mTORC2. In contrast to mTORC1, little is known about the mechanisms that regulate mTORC2. Here we show that mTORC2 activity is reduced in mice with a hypomorphic mutation of the Ric-8B gene. Ric-8B is a highly conserved protein that acts as a non-canon...

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Literature Corpus work: 131de9d0-e3b0-5264-a0e4-b313e6a3ab12
DOI: 10.1101/677054

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