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Article

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development.

Molecular and cellular biology - 1 Nov 2004

Gangloff Yann-Gaël, Mueller Matthias, Dann Stephen G, Svoboda Petr, Sticker Melanie, Spetz Jean-Francois, Um Sung Hee, Brown Eric J, Cereghini Silvia, Thomas George, Kozma Sara C

Abstract excerpt

The mammalian target of rapamycin (mTOR) is a key component of a signaling pathway which integrates inputs from nutrients and growth factors to regulate cell growth. Recent studies demonstrated that mice harboring an ethylnitrosourea-induced mutation in the gene encoding mTOR die at embryonic day 12.5 (E12.5). However, others have shown that the treatment of E4.5 blastocysts with rapamycin blocks trophoblast...

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Identifiers

PMID: 15485918
DOI: 10.1128/MCB.24.21.9508-9516.2004
PMCID: PMC522282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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