Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A kinase-dead knock-in mutation in mTOR leads to early embryonic lethality and is dispensable for the immune system in heterozygous mice.

BMC immunology - 20 May 2009

Shor Boris, Cavender Druie, Harris Crafford

Abstract excerpt

BACKGROUND: The mammalian target of rapamycin protein (mTOR) is an evolutionarily conserved kinase that regulates protein synthesis, cell cycle progression and proliferation in response to various environmental cues. As a critical downstream mediator of PI3K signaling, mTOR is important for lymphocyte development and function of mature T and B-cells. Most studies of mTOR in immune responses have relied on the use...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryonic Development
Share to Gene Knock-In Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune System

Share to Lymphocyte Activation

Share to Phosphatidylinositol 3-Kinases

Share to Phosphotransferases (Alcohol Group Acceptor)

Share to Sirolimus

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 19457267
DOI: 10.1186/1471-2172-10-28
PMCID: PMC2698930

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A kinase-dead knock-in mutation in mTOR leads to early embryonic lethality and is dispensable for the immune system in heterozygous mice.PMID 19457267Read ↗

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells.Semantic proximity Read ↗

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development.Semantic proximity Read ↗

Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability.Semantic proximity Read ↗

Depletion of Ric-8B leads to reduced mTORC2 activitySemantic proximity Read ↗

Tissue-Restricted Inhibition of mTOR Using Chemical GeneticsSemantic proximity Read ↗

Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets.Semantic proximity Read ↗

Premature recruitment of oocyte pool and increased mTOR activity in Fmr1 knockout mice and reversal of phenotype with rapamycin.Semantic proximity Read ↗

The mTOR pathway is necessary for survival of mice with short telomeresSemantic proximity Read ↗

mTOR controls embryonic and adult myogenesis via mTORC1Semantic proximity Read ↗

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells.Semantic proximity Read ↗

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway.Semantic proximity Read ↗

Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.