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Article

S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy.

The Journal of clinical investigation - 1 Jul 2011

Espeillac Catherine, Mitchell Claudia, Celton-Morizur Séverine, Chauvin Céline, Koka Vonda, Gillet Cynthia, Albrecht Jeffrey H, Desdouets Chantal, Pende Mario

Abstract excerpt

Rapamycin is an antibiotic inhibiting eukaryotic cell growth and proliferation by acting on target of rapamycin (TOR) kinase. Mammalian TOR (mTOR) is thought to work through 2 independent complexes to regulate cell size and cell replication, and these 2 complexes show differential sensitivity to rapamycin. Here we combine functional genetics and pharmacological treatments to analyze rapamycin-sensitive mTOR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21633171
DOI: 10.1172/JCI44203
PMCID: PMC3223822

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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