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Article

mTORC2 Signaling Promotes Skeletal Growth and Bone Formation in Mice

4 Sept 2014

Abstract excerpt

Mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase controlling many physiological processes in mammals. mTOR functions in two distinct protein complexes, namely mTORC1 and mTORC2. Compared to mTORC1, the specific roles of mTORC2 are less well understood. To investigate the potential contribution of mTORC2 to skeletal development and homeostasis, we have genetically deleted...

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PMID: 25196701
DOI: 10.1002/jbmr.2348

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