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Article

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E.

Genes & development - 15 Jun 2002

Fingar Diane C, Salama Sofie, Tsou Christina, Harlow Ed, Blenis John

Abstract excerpt

The coordinated action of cell cycle progression and cell growth (an increase in cell size and cell mass) is critical for sustained cellular proliferation, yet the biochemical signals that control cell growth are poorly defined, particularly in mammalian systems. We find that cell growth and cell cycle progression are separable processes in mammalian cells and that growth to appropriate cell size requires mTOR-...

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Identifiers

PMID: 12080086
DOI: 10.1101/gad.995802
PMCID: PMC186342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E.PMID 12080086Read ↗

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