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Article

Genotoxicity of acrylamide and glycidamide.

Journal of the National Cancer Institute - 7 Jul 2004

Besaratinia Ahmad, Pfeifer Gerd P

Abstract excerpt

BACKGROUND: Acrylamide, a known rodent carcinogen, is found in the human diet. However, the mechanism by which acrylamide exerts its carcinogenic effects remains unclear. METHODS: Normal human bronchial epithelial cells and Big Blue mouse embryonic fibroblasts that carry a lambda phage cII transgene were treated in vitro with acrylamide, its primary epoxide metabolite glycidamide, or water (control) and then...

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Identifiers

PMID: 15240786
DOI: 10.1093/jnci/djh186

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