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Article

Mutagenicity of aristolochic acid in the lambda/lacZ transgenic mouse (MutaMouse).

Mutation research - 25 Mar 2002

Kohara Arihiro, Suzuki Takayoshi, Honma Masamitsu, Ohwada Tomohiko, Hayashi Makoto

Abstract excerpt

Aristolochic acid (AA) is found in a plant that causes urothelial carcinomas in patients with Chinese herb nephropathy (CHN). To evaluate the in vivo mutagenicity of AA, we analysed the mutant frequency (MF) in the lacZ and cII gene of 10 organs of the lambda/lacZ transgenic mouse (MutaMouse) after intragastric treatment with AA (15mg/kg per week x 4). Simultaneously, the clastogenicity of AA was evaluated by the...

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PMID: 11909755
DOI: 10.1016/s1383-5718(01)00350-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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