In vivo cII, gpt, and Spi⁻ gene mutation assays in transgenic mice and rats.

doi:10.1007/978-1-62703-529-3_5

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Article

In vivo cII, gpt, and Spi⁻ gene mutation assays in transgenic mice and rats.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013

Manjanatha Mugimane G, Cao Xuefei, Shelton Sharon D, Mittelstaedt Roberta A, Heflich Robert H

Abstract excerpt

Transgenic mutation assays are used to identify and characterize genotoxic hazards and for determining the mode of action for carcinogens. The three most popular transgenic mutational models are Big Blue® (rats or mice), Muta™ mouse (mice), and gpt-delta (rats or mice). The Big Blue® and Muta™ mouse models use the cII gene as a reporter of mutation whereas gpt-delta rodents use the gpt gene and the red/gam genes...

Topics

Animals
DNA
DNA Mutational Analysis
DNA Packaging
Escherichia coli
Escherichia coli Proteins
Genetic Loci
Intercellular Signaling Peptides and Proteins
Mice
Mice, Transgenic
Mutagenicity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Pentosyltransferases

Peptides

Phenotype

Rats

Rats, Transgenic

Tissue and Organ Harvesting

Source

Open in PubMed

Identifiers

PMID: 23896873
DOI: 10.1007/978-1-62703-529-3_5

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