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Article

Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay.

International journal of cancer - 1 Nov 2012

Von Tungeln Linda S, Doerge Daniel R, Gamboa da Costa Gonçalo, Matilde Marques M, Witt William M, Koturbash Igor, Pogribny Igor P, Beland Frederick A

Abstract excerpt

Acrylamide is a high-volume industrial chemical, a component of cigarette smoke, and a product formed in certain foods prepared at high temperatures. Previously, we compared the extent of DNA adduct formation and mutations in B6C3F(1) /Tk mice treated neonatally with acrylamide or glycidamide to obtain information concerning the mechanism of acrylamide genotoxicity. We have now examined the tumorigenicity of...

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Identifiers

PMID: 22336951
DOI: 10.1002/ijc.27493
PMCID: PMC4810677

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