Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay.

doi:10.1002/ijc.27493

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Article

Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay.

International journal of cancer - 1 Nov 2012

Von Tungeln Linda S, Doerge Daniel R, Gamboa da Costa Gonçalo, Matilde Marques M, Witt William M, Koturbash Igor, Pogribny Igor P, Beland Frederick A

Abstract excerpt

Acrylamide is a high-volume industrial chemical, a component of cigarette smoke, and a product formed in certain foods prepared at high temperatures. Previously, we compared the extent of DNA adduct formation and mutations in B6C3F(1) /Tk mice treated neonatally with acrylamide or glycidamide to obtain information concerning the mechanism of acrylamide genotoxicity. We have now examined the tumorigenicity of...

Topics

Acrylamide
Adenoma, Liver Cell
Animals
Animals, Newborn
Carcinogenicity Tests
Carcinogens
DNA Adducts
DNA Damage
Epoxy Compounds
Female
Genes, ras

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver

Liver Neoplasms

Male

Mice

Mice, Inbred C3H

Mice, Inbred C57BL

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 22336951
DOI: 10.1002/ijc.27493
PMCID: PMC4810677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22336951-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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