Article
Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice.
Environmental and molecular mutagenesis - 1 Jan 2006
Manjanatha Mugimane G, Aidoo Anane, Shelton Sharon D, Bishop Michelle E, McDaniel Lea P, Lyn-Cook Lascelles E, Doerge Daniel R
Abstract excerpt
The recent discovery of acrylamide (AA), a probable human carcinogen, in a variety of fried and baked starchy foods has drawn attention to its genotoxicity and carcinogenicity. Evidence suggests that glycidamide (GA), the epoxide metabolite of AA, is responsible for the genotoxic effects of AA. To investigate the in vivo genotoxicity of AA, groups of male and female Big Blue (BB) mice were administered 0, 100, or...
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