Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice.

doi:10.1002/em.20157

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Article

Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice.

Environmental and molecular mutagenesis - 1 Jan 2006

Manjanatha Mugimane G, Aidoo Anane, Shelton Sharon D, Bishop Michelle E, McDaniel Lea P, Lyn-Cook Lascelles E, Doerge Daniel R

Abstract excerpt

The recent discovery of acrylamide (AA), a probable human carcinogen, in a variety of fried and baked starchy foods has drawn attention to its genotoxicity and carcinogenicity. Evidence suggests that glycidamide (GA), the epoxide metabolite of AA, is responsible for the genotoxic effects of AA. T...

Topics

Acrylamide
Animals
Epoxy Compounds
Female
Hypoxanthine Phosphoribosyltransferase
Liver
Lymphocytes
Male
Mice
Mice, Transgenic
Micronuclei, Chromosome-Defective

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Micronucleus Tests

Mutagens

Mutation

Transcription Factors

Viral Proteins

Water Supply

Source

Open in PubMed

Identifiers

PMID: 15957192
DOI: 10.1002/em.20157

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-15957192-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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