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Article

DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide.

International journal of cancer - 1 May 2009

Von Tungeln Linda S, Churchwell Mona I, Doerge Daniel R, Shaddock Joseph G, McGarrity Lynda J, Heflich Robert H, Gamboa da Costa Gonçalo, Marques M Matilde, Beland Frederick A

Abstract excerpt

Acrylamide, a food contaminant, is carcinogenic in experimental animals, with both genotoxic and nongenotoxic pathways being proposed. To obtain information regarding mechanisms of acrylamide tumorigenesis, we compared the extent of DNA adduct formation and induction of micronuclei and mutations in mice treated neonatally with acrylamide and its electrophilic metabolite glycidamide. Male and female B6C3F1/Tk mice...

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PMID: 19123476
DOI: 10.1002/ijc.24165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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