Article
DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide.
International journal of cancer - 1 May 2009
Von Tungeln Linda S, Churchwell Mona I, Doerge Daniel R, Shaddock Joseph G, McGarrity Lynda J, Heflich Robert H, Gamboa da Costa Gonçalo, Marques M Matilde, Beland Frederick A
Abstract excerpt
Acrylamide, a food contaminant, is carcinogenic in experimental animals, with both genotoxic and nongenotoxic pathways being proposed. To obtain information regarding mechanisms of acrylamide tumorigenesis, we compared the extent of DNA adduct formation and induction of micronuclei and mutations...
Topics
- Acrylamide
- Animals
- Animals, Newborn
- Body Weight
- Cell Nucleus
- DNA Adducts
- Epoxy Compounds
- Erythrocytes
- Female
- Hypoxanthine Phosphoribosyltransferase
- Loss of Heterozygosity
- Lymphocytes
- Male
- Mice