In vitro recapitulating of TP53 mutagenesis in hepatocellular carcinoma associated with dietary aflatoxin B1 exposure.

doi:10.1053/j.gastro.2009.06.002

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Article

In vitro recapitulating of TP53 mutagenesis in hepatocellular carcinoma associated with dietary aflatoxin B1 exposure.

Gastroenterology - 1 Sept 2009

Besaratinia Ahmad, Kim Sang-In, Hainaut Pierre, Pfeifer Gerd P

Abstract excerpt

BACKGROUND & AIMS: Dietary exposure to aflatoxin B(1) (AFB(1)), in addition to other known factors, increases risk for human hepatocellular carcinoma (HCC). HCCs from AFB(1)-exposed individuals frequently have distinct TP53 mutations, such as G to T transversions in the second guanine of codon 249 (AGG to AGT), and a characteristic mutational spectrum predominated by G:C to T:A mutations. METHODS: To recapitulate...

Topics

Aflatoxin B1
Animals
Carcinogens
Carcinoma, Hepatocellular
Cells, Cultured
DNA Adducts
DNA Damage
Dose-Response Relationship, Drug
Fibroblasts
Genes, p53
Liver Neoplasms
Mice
Mice, Transgenic
Mutagenicity Tests
Mutation

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PMID: 19524575
DOI: 10.1053/j.gastro.2009.06.002
PMCID: PMC2736365

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