Article
Acrylamide-induced carcinogenicity in mouse lung involves mutagenicity: cII gene mutations in the lung of big blue mice exposed to acrylamide and glycidamide for up to 4 weeks.
Environmental and molecular mutagenesis - 1 Jun 2015
Manjanatha Mugimane G, Guo Li-Wu, Shelton Sharon D, Doerge Daniel R
Abstract excerpt
Potential health risks for humans from exposure to acrylamide (AA) and its epoxide metabolite glycidamide (GA) have garnered much attention lately because substantial amounts of AA are present in a variety of fried and baked starchy foods. AA is tumorigenic in rodents, and a large number of in vitro and in vivo studies indicate that AA is genotoxic. A recent cancer bioassay on AA demonstrated that the lung was...
Topics
- Acrylamide
- Administration, Oral
- Animals
- DNA
- Dose-Response Relationship, Drug
- Epoxy Compounds
- Female
- Lung Neoplasms
- Male
- Mice, Inbred Strains
- Mutagens