Differential genotoxicity of acrylamide in the micronucleus and Pig-a gene mutation assays in F344 rats and B6C3F1 mice.

doi:10.1093/mutage/gew028

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Article

Differential genotoxicity of acrylamide in the micronucleus and Pig-a gene mutation assays in F344 rats and B6C3F1 mice.

Mutagenesis - 1 Nov 2016

Hobbs Cheryl A, Davis Jeffrey, Shepard Kim, Chepelev Nikolai, Friedman Marvin, Marroni Dennis, Recio Leslie

Abstract excerpt

Acrylamide is used in many industrial processes and is present in a variety of fried and baked foods. In rodent carcinogenicity assays, acrylamide exposure leads to tumour formation at doses lower than those demonstrated to induce genotoxic damage. We evaluated the potential of acrylamide to indu...

Topics

Acrylamide
Animals
DNA
DNA Damage
Male
Mice
Mice, Inbred Strains
Micronuclei, Chromosome-Defective
Mutagenicity Tests
Mutation
Rats
Rats, Inbred F344

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