Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential genotoxicity of acrylamide in the micronucleus and Pig-a gene mutation assays in F344 rats and B6C3F1 mice.

Mutagenesis - 1 Nov 2016

Hobbs Cheryl A, Davis Jeffrey, Shepard Kim, Chepelev Nikolai, Friedman Marvin, Marroni Dennis, Recio Leslie

Abstract excerpt

Acrylamide is used in many industrial processes and is present in a variety of fried and baked foods. In rodent carcinogenicity assays, acrylamide exposure leads to tumour formation at doses lower than those demonstrated to induce genotoxic damage. We evaluated the potential of acrylamide to induce structural DNA damage and gene mutations in rodents using highly sensitive flow cytometric analysis of micronucleus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA
Share to DNA Damage
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred Strains

Share to Mutagenicity Tests

Share to Mutation

Share to Rats, Inbred F344

Source

Identifiers

PMID: 27338305
DOI: 10.1093/mutage/gew028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential genotoxicity of acrylamide in the micronucleus and Pig-a gene mutation assays in F344 rats and B6C3F1 mice.PMID 27338305Read ↗

Experimental analysis of exome-scale mutational signature of glycidamide, the reactive metabolite of acrylamideSemantic proximity Read ↗

Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.Semantic proximity Read ↗

Integration of liver and blood micronucleus and Pig-a gene mutation endpoints into rat 28-day repeat-treatment studies: Proof-of-principle with diethylnitrosamine.Semantic proximity Read ↗

Report on stage III Pig-a mutation assays using N-ethyl-N-nitrosourea-comparison with other in vivo genotoxicity endpoints.Semantic proximity Read ↗

DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide.Semantic proximity Read ↗

Genotoxicity of acrylamide and glycidamide.Semantic proximity Read ↗

The genotoxicity of acrylamide and glycidamide in big blue rats.Semantic proximity Read ↗

Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice.Semantic proximity Read ↗

Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay.Semantic proximity Read ↗

Comparison of germ cell mutagenicity in male CYP2E1-null and wild-type mice treated with acrylamide: evidence supporting a glycidamide-mediated effect.Semantic proximity Read ↗

N-Nitrosodimethylamine investigations in Muta™Mouse define point-of-departure values and demonstrate less-than-additive somatic mutant frequency accumulations.Semantic proximity Read ↗

Comparison of integrated genotoxicity endpoints in rats after acute and subchronic oral doses of 4-nitroquinoline-1-oxide.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.