Article
The genotoxicity of acrylamide and glycidamide in big blue rats.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Jun 2010
Mei Nan, McDaniel Lea P, Dobrovolsky Vasily N, Guo Xiaoqing, Shaddock Joseph G, Mittelstaedt Roberta A, Azuma Mizuo, Shelton Sharon D, McGarrity Lynda J, Doerge Daniel R, Heflich Robert H
Abstract excerpt
Acrylamide (AA), a mutagen and rodent carcinogen, recently has been detected in fried and baked starchy foods, a finding that has prompted renewed interest in its potential for toxicity in humans. In the present study, we exposed Big Blue rats to the equivalent of approximately 5 and 10 mg/kg body weight/day of AA or its epoxide metabolite glycidamide (GA) via the drinking water, an AA treatment regimen...
Topics
- Acrylamide
- Animals
- DNA Mutational Analysis
- Epoxy Compounds
- Female
- Hypoxanthine Phosphoribosyltransferase
- Lymphocytes
- Male
- Micronuclei, Chromosome-Defective
- Micronucleus Tests