Article
Evaluation of cII gene mutation in the brains of Big Blue mice exposed to acrylamide and glycidamide in drinking water.
The Journal of toxicological sciences - 1 Jan 2016
Li Hai-Fang, Shelton Sharon D, Townsend Todd A, Mei Nan, Manjanatha Mugimane G
Abstract excerpt
Potential health risks for humans from dietary exposure to acrylamide (AA) and its reactive epoxide metabolite, glycidamide (GA), exist because substantial amounts of AA are found in a variety of fried and baked starchy foods. AA is tumorigenic in rodents, and a large number of studies indicate t...
Topics
- Acrylamide
- Administration, Oral
- Animals
- Brain
- DNA Mutational Analysis
- Dose-Response Relationship, Drug
- Drinking Water
- Epoxy Compounds
- Female
- Male
- Mice, Transgenic
- Mutagenesis
- Mutagenicity Tests
- Mutation
- Sex Factors
- Transcription Factors
- Viral Proteins
- Water Pollutants, Chemical