Article
Timing and checkpoints in the regulation of mitotic progression.
Developmental cell - 1 Jul 2004
Meraldi Patrick, Draviam Viji M, Sorger Peter K
Abstract excerpt
Accurate chromosome segregation relies on the precise regulation of mitotic progression. Regulation involves control over the timing of mitosis and a spindle assembly checkpoint that links anaphase onset to the completion of chromosome-microtubule attachment. In this paper, we combine live-cell imaging of HeLa cells and protein depletion by RNA interference to examine the functions of the Mad, Bub, and...
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