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Article

Drosophila CENP-A mutations cause a BubR1-dependent early mitotic delay without normal localization of kinetochore components.

PLoS genetics - 1 Jul 2006

Blower Michael D, Daigle Tanya, Kaufman Thom, Karpen Gary H

Abstract excerpt

The centromere/kinetochore complex plays an essential role in cell and organismal viability by ensuring chromosome movements during mitosis and meiosis. The kinetochore also mediates the spindle attachment checkpoint (SAC), which delays anaphase initiation until all chromosomes have achieved bipolar attachment of kinetochores to the mitotic spindle. CENP-A proteins are centromere-specific chromatin components...

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Identifiers

PMID: 16839185
DOI: 10.1371/journal.pgen.0020110
PMCID: PMC1500813

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