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Cell cycle checkpoints: Arresting progress in mitosis

1 Mar 1997

Abstract excerpt

Cell cycle arrest in M phase can be induced by the failure of a single chromosome to attach properly to the mitotic spindle. The same cell cycle checkpoint mediates M phase arrest when cells are treated with drugs that either disrupt or hyperstabilize spindle microtubules. Study of yeast mutants that fail to arrest in the presence of microtubule disruptors identified a set of genes important in this checkpoint...

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PMID: 9103187
DOI: 10.1002/bies.950190303

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