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Article

A mitotic role for Mad1 beyond the spindle checkpoint.

Journal of cell science - 15 May 2011

Emre Doruk, Terracol Régine, Poncet Anaïs, Rahmani Zohra, Karess Roger E

Abstract excerpt

Unattached kinetochores generate an anaphase inhibitor, through the spindle assembly checkpoint (SAC), that allows cells more time to establish proper kinetochore-microtubule (K-MT) linkages and thus avoid aneuploidy. Mad1 is the receptor for Mad2 at kinetochores, where it catalyzes the formation of Mad2-Cdc20 complexes, an essential part of the anaphase inhibitor, but whether it has any other mitotic function is...

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Identifiers

PMID: 21511728
DOI: 10.1242/jcs.081216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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