Mad2-independent spindle assembly checkpoint activation and controlled metaphase-anaphase transition in Drosophila S2 cells.

doi:10.1091/mbc.e06-07-0587

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Article

Mad2-independent spindle assembly checkpoint activation and controlled metaphase-anaphase transition in Drosophila S2 cells.

Molecular biology of the cell - 1 Mar 2007

Orr Bernardo, Bousbaa Hassan, Sunkel Claudio E

Abstract excerpt

The spindle assembly checkpoint is essential to maintain genomic stability during cell division. We analyzed the role of the putative Drosophila Mad2 homologue in the spindle assembly checkpoint and mitotic progression. Depletion of Mad2 by RNAi from S2 cells shows that it is essential to prevent...

Topics

Anaphase
Animals
Cell Cycle Proteins
Drosophila Proteins
Drosophila melanogaster
Kinetochores
Mad2 Proteins
Metaphase
Phenotype
RNA Interference
Sister Chromatid Exchange
Spindle Apparatus

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