Article
A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children.
AIDS (London, England) - 23 Jul 2004
Braida Laura, Boniotto Michele, Pontillo Alessandra, Tovo Pier Angelo, Amoroso Antonio, Crovella Sergio
Abstract excerpt
In this study we show a significant correlation between a single-nucleotide polymorphism in the 5'-untranslated region of the DEFB1 gene, which probably regulates the gene expression of human beta defensin 1 (hBD-1) and the risk of HIV-1 infection in an Italian paediatric population (97 HIV-1 perinatally infected children), pointing to the importance of innate immunity in HIV-1 infection.
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.