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Article

Impact of DEFB1 gene regulatory polymorphisms on hBD-1 salivary concentration.

Archives of oral biology - 1 Jul 2015

Polesello Vania, Zupin Luisa, Di Lenarda Roberto, Biasotto Matteo, Ottaviani Giulia, Gobbo Margherita, Cecco Luca, Alberi Giulia, Pozzato Gabriele, Crovella Sergio, Segat Ludovica

Abstract excerpt

OBJECTIVES: Human β-defensin 1 (hBD-1) is an antimicrobial peptide involved in epithelial defence of various tissues, also present in the saliva. Individual genetic variations within the DEFB1 gene, encoding for hBD-1, could influence gene expression and protein production. DESIGN: Three DEFB1 polymorphisms at 5' untranslated region (UTR), -52G > A (rs1799946), -44C > G (rs1800972) and -20G > A (rs11362), and two...

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Identifiers

PMID: 25939140
DOI: 10.1016/j.archoralbio.2015.03.009

Genes

DEFB1

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