Article
DEFB1 gene polymorphisms and increased risk of HIV-1 infection in Brazilian children.
AIDS (London, England) - 1 Aug 2006
Milanese Michele, Segat Ludovica, Pontillo Alessandra, Arraes Luiz Claudio, de Lima Filho José Luiz, Crovella Sergio
Abstract excerpt
In our study we analysed three single nucleotide polymorphisms (SNPs) in the 5' untranslated region (UTR) of the DEFB1 gene, namely -52(G/A) -44(C/G) and -20(G/A), in three groups of northeastern Brazilian children in order to assess their role in HIV-1 infection. Our results allowed us to hypothesize that the SNPs located in the 5' UTR of the DEFB1 gene can be employed as a marker of risk for HIV-1 infection.
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