Article
DEFB1 5'UTR polymorphisms modulate the risk of HIV-1 infection in Mexican women.
Current HIV research - 1 Jan 2014
Estrada-Aguirre J A, Osuna-Ramírez I, Prado Montes de Oca E, Ochoa-Ramirez L A, Ramirez M, Magallon-Zazueta L G, Gonzalez-Beltran M S, Cazarez-Salazar S G, Rangel-Villalobos H, Velarde-Felix J S
Abstract excerpt
Immunologic and genetic factors are involved in HIV-1/AIDS pathogenesis. Defensins are key molecules in innate immunity that participate in the control and/or development of infection and disease. Using PCR-RFLPs, we determined the association between HIV-1/AIDS and human β-defensin 1 (DEFB1) 5'UTR -52 G/A (rs1799946), -44 C/G (rs1800972), and -20 G/A (rs11362) polymorphisms in three groups of women from the...
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