Transcriptional Effect of DEFB1 Gene 5′ Untranslated Region Polymorphisms

Abstract excerpt

To the Editor: Human β-defensin-1 (hBD-1) has been shown to be a candidate tumor suppressor gene by Sun et al. (1) who reported that single nucleotide polymorphisms (SNP) in the DEFB1 gene are able to modify the transcriptional activity of hBD-1 promoter. In particular, the −44C/G SNP was described to enhance transcription up to 2.3 times more than the wild-type sequence in DU145 or TSU-Pr1 cell lines.Recently,...

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